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Protein crystallisation
HomeBase - management of protein crystallisation experiments
Protein crystallisation is inherently difficult because of the fragile nature of protein crystals. In addition, the successful production of x-ray worthy crystals is dependent upon a number of environmental factors because so much variation exists among proteins, with each individual requiring unique conditions for successful crystallisation. Therefore, attempting to crystallise a protein without a proven protocol can be very tedious.
  HomeBase has been optimised to provide all of the physical requirements needed for successful protein crystallisation experiments:
 
  • Protein environmental control to maximise the growth of protein crystal
  • Smooth vibration-free robotics to minimise crystal degradation and avoid disturbance of plate droplets
  • Flexibility of design that allows sitting and hanging-drop vapour diffusion plates
  • Storage, retrieval and visualisation of a large number of experiments
  For MPI's protein structure analysis factory, HomeBase holds 10,000 special plates in which delicate crystals are grown in storage conditions of +19°C (+/-0.5°C).
 
  • The Max Planck Institute of Molecular Genetics (MPI) and
    The Wellcome Trust Centre for Human Genetics at the University of Oxford
    chose HomeBase as the plate handling system for their protein crystallation experiments.
  For more information visit, SMS Systems - HomeBase System Overview

 

Both MPI and The Wellcome Trust Centre have published posters on the use of HomeBase in protein crystallisation experiments, and PDF's of these posters can be viewed or downloaded below
 
Wellcome Trust Poster
MPI Poster
  For more information on protein crystalisation
  Get more details on TAP's SMS Systems
  Discuss your requirements with Ian Ransome, Sales Director
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