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Protein crystallisation
is inherently difficult because of the fragile
nature of protein crystals. In addition,
the successful production of x-ray worthy
crystals is dependent upon a number of environmental
factors because so much variation exists
among proteins, with each individual requiring
unique conditions for successful crystallisation.
Therefore, attempting to crystallise a protein
without a proven protocol can be very tedious. |
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HomeBase
has been optimised to provide all of the
physical requirements needed for successful
protein crystallisation experiments: |
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- Protein environmental control to
maximise the growth of protein crystal
- Smooth vibration-free robotics to
minimise crystal degradation and avoid
disturbance of plate droplets
- Flexibility of design that allows
sitting and hanging-drop vapour diffusion
plates
- Storage, retrieval and visualisation
of a large number of experiments
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For MPI's protein
structure analysis factory, HomeBase holds
10,000 special plates in which delicate
crystals are grown in storage conditions
of +19°C (+/-0.5°C). |
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- The Max
Planck Institute of Molecular Genetics
(MPI) and
The Wellcome Trust Centre for Human
Genetics at the University of Oxford
chose HomeBase as the plate handling
system for their protein crystallation
experiments.
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For more information
visit, SMS
Systems - HomeBase System Overview |
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Both MPI and
The Wellcome Trust Centre have published
posters on the use of HomeBase in protein
crystallisation experiments, and PDF's of
these posters can be viewed or downloaded
below |
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For
more information on protein crystalisation |
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Get more
details on TAP's
SMS Systems |
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Discuss
your requirements with Ian
Ransome, Sales Director |
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Back to key applications in Sample Management
& Screening |
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