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Piccolo™
is a new, fully automated system for the rapid optimisation
of recombinant protein production in microbial or
insect cells. |
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The system has been
designed in conjunction with a consortium of 3 leading
global pharmaceutical companies and offers the flexibility
to vary and control a wide range of protein culture
parameters independently and conduct experiments
in parallel. |
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- Culture inoculation/infection
- Growth/induction
- Harvest
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- Lysis
- Affinity purification
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- Significant reduction in protein production
timelines
(from months to days)
- Improved run-to-run consistency and site-to-site
process transfer
- Provision of improved data for experimental
strategy design
- Focus on maintaining protein quality
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Piccolo
enables consistent and reliable determination of
the best construct, host strain, culture conditions
and induction/infection dynamics for individual
target proteins. |
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- Structural biology
- Assay development
- Protein engineering
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Piccolo
is currently being implemented by 3 leading global
pharmaceutical companies. |
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